产品货号：
Z24239
中文名称：
PRDX4抗体
英文名称：
Anti-PRDX4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PRDX4 Antibody |
| 指标别名 | Antioxidant enzyme AOE372;AOE37 2;peroxiredoxin 4;Peroxiredoxin IV;PRDX4;PRX 4;Prx IV;Thioredoxin peroxidase AO372 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | PRDX4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 4 (178-2081aa SDLTHQISKDYGVYLEDSGHTLRGLFIIDDK),different from the related mouse and rat sequences by one amino acid. |
| 实际分子量 | 31KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PRDX4 (peroxiredoxin 4) is also known as AOE37-2.The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family.Functional analysis showed that PRDX4 protects glutamine synthetase from inactivation.Yeast 2-hybrid,immunoprecipitation,and immunoblot analyses indicated that PRDX4 and PRDX1 are capable of homodimerization and heterodimerization with each other but not with the mitochondrial PRDX3.Gel mobility shift and immunoblot analysis found that PRDX4 depletes NFKB binding activity together with a reduction in the amounts of p50,p65,and phosphorylated IKBA,as well as a reduction in the expression of HIV-1 viral proteins.Expression of PRDX4,alone or with PRDX1,increased the resistance of yeast cells to oxidant-induced toxicity.Jin et al.suggested PRDX4 modulates IKBA phosphorylation in the cytoplasm and thus affects a peroxiredoxin-dependent redox step. |
| Uniprot ID | Q13162 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | peroxiredoxin 4 |
| 蛋白名全称 | Peroxiredoxin-4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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